Radio-pharmaceutical Preparation


This short report will discuss the key aspects of radiopharmaceutical preparation. It will define and discuss aseptic and radiation safety techniques in the Hot Lab. Moreover, it will throw light on misadministration and state minimization techniques that can be employed to mitigate this risk.


Aseptic techniques to be used during radiopharmaceutical preparation

Aseptic technique is a process of preventing environment from spreading of infections caused by harmful microorganisms. Such techniques minimizes the risk of spreading of infections exactly at the source (1).

Various aseptic techniques are required to be practiced during radiopharmaceutical preparation. Firstly, special clothes and sterilized gloves should be worn. Secondly, sterilized vials, needles, diluents and syringes should be used for maintaining the high quality of the radiopharmaceuticals. Lastly, an aseptic work environment must be maintained by controlling air quality that inhibits the spreading of microorganisms (2).


Radiation safety and its techniques for the Hot Lab

Radiation safety is defined as protecting people from destructive effects of ionizing radiation by adopting procedures that ensure safe handling of radioactive sources and materials.

Radiation safety techniques basically reduces the risk while being exposed to ionizing radiation. There are various radiation safety techniques which are employed in Hot Lab. Firstly, radiation area should be kept tidy and covered with absorbent paper. Secondly, radioactive materials, when not being used, must be placed away from radiation work area. Each radioactive material must be labelled with a warning sign. Personnel should wear lab coats and gloves while handling these materials. Smoking is inhibited in radioactive areas. Lastly, radioactive materials should not be mouth-pipetted, rather bulbs or syringes must be used for this purpose (3).


Misadministration and its minimization techniques

Misadministration is defined as the administration of amount of a radioactive substance which exceeds the prescribed dosage limit. It also means administration of correct dosage of wrong substance, or to the wrong patient; and administration by non-prescribed route (4).

In order to reduce risks exposed by misadministration in the Hot Lab, various techniques can be employed. For example, the lab must formulate and monitor guidelines which clearly detail the usage, dosage and associated risks of each radioactive material. The materials must be used by authorized personnel only. Most importantly, each case of misadministration must be documented and notified by the management, so that future personnel avoid repeating such mistakes.



This short report has discussed the key aspects of radiopharmaceutical preparation. It defined and discussed aseptic and radiation safety techniques to be used in the Hot Lab. Additionally, it threw light on misadministration and stated its minimization techniques.



  1. Cherney K. Healhtline [Internet]. [Place unkown]: [Publisher unknown]; 2013 [cited 2014 August 9]. Available from:
  2. Guidelines on current good radiopharmacy practice (cGRPP) in the preparation of radiopharmaceuticals [Internet]. [Place unknown]: EANM radiopharmacy committee; 2007 [cited 2014 August 9]. Available from:
  3. Radiation safety handbook [Internet]. Northwestern University: Office for research; 2010 [cited 2014 August 9]. Available from:
  4. Gottfreid, K-L D, Pen, G, editor. Radiation in medicine: a need for regulatory reform. Washington, D.C.: National academy press; 1996.
Can’t decide? Try 500 words FREE OF CHARGE!